| Autor: |
David Eduardo Barroso, MD PhD, D.M. Carvalho, S.T. Casagrande, M.C. Rebelo, V. Soares, V. Zahner, C.A. Solari, S.A. Nogueira |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Infectious Diseases, Vol 14, Iss 3, Pp 242-251 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1413-8670 |
| DOI: |
10.1016/S1413-8670(10)70051-9 |
| Popis: |
The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a significant shift in the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and early management of suspected cases. Keywords: Neisseria meningitidis, meningococcal disease, epidemic, meningitis, sepsis |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
