Assessment of Immunohistochemical Expression of Fascin in Breast Carcinoma: A Cross-sectional Study
| Autor: | Priyanka Verma, Nisha Marwah, Sanjeev Parshad, Usha Rani, Monika Gupta, Renuka Verma, Sunita Singh |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 18, Iss 11, Pp 17-20 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2024/73550.20348 |
| Popis: | Introduction: Fascin is an actin-binding protein that mediates invasion by modulating metastasis-associated genes. Fascin expression in breast carcinoma is correlated with clinical aggressiveness, metastasis, histological subtype and shorter disease-free survival. Aim: To evaluate fascin expression through Immunohistochemistry (IHC) and its association with clinicopathological parameters in breast cancer. Materials and Methods: This cross-sectional study was conducted in the Department of Pathology and Surgery at Pandit B. D. Sharma PGIMS, Rohtak, Haryana, India, from May 1, 2021, to April 30, 2022. A total of 80 cases of breast carcinoma were included in the study. The IHC detection of fascin expression was evaluated in relation to the molecular subtypes of breast carcinoma {luminal A, luminal B, human epidermal growth factor receptor 2 (HER2), and Triple-Negative (TN)} and other clinicopathological factors, including age, grade, tumour size, stage, regional lymph node status and survival. The collected data were categorised, compiled, tabulated, and analysed using Statistical Package for Social Sciences (SPSS) version 24.0. Associations were tested using Pearson’s Chi-square and Fisher’s exact tests. A p-value |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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