| Autor: |
Cristina Veronica Trinidad Esparza, Maria J. Lizardo-Thiebaud, María Graciela Leal-Gutierrez, Beatriz Sánchez-Hernandez, Daniel Montante Montes de Oca |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Surgical and Experimental Pathology, Vol 5, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2520-8454 |
| DOI: |
10.1186/s42047-022-00110-0 |
| Popis: |
Abstract Background Therapy-related acute monocytic leukemias in patients with plasma cell dyscrasias are infrequent. Case presentation We here present a case of a 60 year old female who developed an acute monocytic leukemia two years after the diagnosis of multiple myeloma. She was treated with an alkylating agent and bortezomib before undergoing a hematopoietic stem cell transplantation. She suffered of multiple severe infections until her immune system was adequately reconstituted. A year afterwards, she presented signs of deterioration unrelated to the MM, with pancytopenia. The bone marrow aspirate failed to show a prominent blast population. The diagnosis of AML was confirmed after a bone marrow biopsy. Discussion The development of acute leukaemia after treatment for multiple myeloma is a well characterized phenomenon. Most frequently, patients develop a myelomonocytic leukemia. Similarly, synchronous acute myeloid leukemias are myelomonocytic or myeloblastic. Rarely synchronous AMLs are monocytic. The development of such suggests a dysfunctional bone marrow microenvironment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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