N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives

Autor:	György Orsy, Ferenc Fülöp, István M. Mándity
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	flow chemistry acetylation acetonitrile safe green chemistry Organic chemistry QD241-441
Zdroj:	Molecules, Vol 25, Iss 8, p 1985 (2020)
Druh dokumentu:	article
ISSN:	25081985 1420-3049
DOI:	10.3390/molecules25081985
Popis:	A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good conversion. The catalyst showed excellent reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol) was also synthesized with good conversion and yield.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1d1d90260ad74ef0b4abcdd3cc68aefc Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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