Leveraging the Cell Ontology to classify unseen cell types

Autor: Sheng Wang, Angela Oliveira Pisco, Aaron McGeever, Maria Brbic, Marinka Zitnik, Spyros Darmanis, Jure Leskovec, Jim Karkanias, Russ B. Altman
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25725-x
Popis: Classifying cells into unseen cell types remains challenging in scRNA-seq analysis. Here we show that Cell Ontology enables an accurate classification of unseen cell types through considering the cell type relationships in the Cell Ontology graph.
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