| Autor: |
Luís Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Luísa Correia Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Yvana Baumgarth, Luís Matos de Oliveira |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Archives of Endocrinology and Metabolism, Vol 68 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2359-4292 |
| DOI: |
10.20945/2359-4292-2023-0248 |
| Popis: |
ABSTRACT Objective To analyze in silico the evidence of molecular mimicry between human beta-cell autoantigens and cow’s milk proteins as a potential type 1 diabetes mellitus (T1DM) trigger. Materials and methods The in silico analysis was performed using bioinformatics tools to compare the amino acid sequences of cow’s milk proteins (bovine serum albumin [BSA] and beta-lactoglobulin [BLG]) and human beta-cell autoantigens (glutamic acid decarboxylase-65 [GAD-65], insulin, and zinc transporter 8 [ZnT8]). The structural and functional characteristics of the proteins were analyzed to identify potential molecular mimicry mechanisms. Results The results of the in silico analysis showed significant sequence similarity between BSA/BLG and GAD-65/human insulin/ZnT8, ranging from 19.64% to 27.27%. The cow’s milk proteins evaluated shared structural features with the beta-cell antigens selected for comparison, indicating a potential for molecular mimicry between these proteins. Conclusion The findings of this study provide further evidence for a potential role of cow’s milk proteins in triggering T1DM. The in silico analysis suggests that molecular mimicry mechanisms between cow’s milk proteins and human beta-cell antigens may contribute to the autoimmune response leading to T1DM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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