Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients
Autor: | Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: | |
Zdroj: | EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-6 (2018) |
Druh dokumentu: | article |
ISSN: | 1757-4676 1757-4684 63697939 |
DOI: | 10.15252/emmm.201809323 |
Popis: | Abstract Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole‐genome sequencing (sWGS, at a coverage of |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |
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