Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Autor: Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: EMBO Molecular Medicine, Vol 10, Iss 12, Pp 1-6 (2018)
Druh dokumentu: article
ISSN: 1757-4676
1757-4684
63697939
DOI: 10.15252/emmm.201809323
Popis: Abstract Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole‐genome sequencing (sWGS, at a coverage of
Databáze: Directory of Open Access Journals
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