Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in a cohort of students and post-graduates of the Medical School at the University of Palermo, Italy
| Autor: | MG Verso, N Lo Cascio, E Noto Laddeca, E Amodio, M Currieri, G Giammanco, D Ferraro, S De Grazia, D Picciotto |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Annals of Agricultural and Environmental Medicine, Vol 24, Iss 2, Pp 303-306 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1232-1966 1898-2263 |
| DOI: | 10.26444/aaem/74716 |
| Popis: | Introduction and objective The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in 1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of the prevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectiveness of HBV vaccination among healthcare students with different working seniorities. Material and Methods A cross-sectional observational study of undergraduate and postgraduate students attending the Medical School of the University of Palermo was conducted from January 2014 – July 2016. HBV serum markers were performed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test (Mantel–Haenszel), whereas means were compared by using the Student’s t test. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examine predictors of anti-HBs titer above 10 mIU/mL, assumed as protective. Results Of the 2,114 subjects evaluated – all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBc negative – 806 (38.1%) had an anti-HBs titre |
| Databáze: | Directory of Open Access Journals |
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