3D Tortuosity computation as a shape descriptor and its application to brain structure analysis

Autor: Maria-Julieta Mateos, Ernesto Bribiesca, Adolfo Guzmán-Arenas, Wendy Aguilar, Jorge A. Marquez-Flores
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Medical Imaging, Vol 24, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 1471-2342
DOI: 10.1186/s12880-024-01312-6
Popis: Abstract In this study, we propose a novel method for quantifying tortuosity in 3D voxelized objects. As a shape characteristic, tortuosity has been widely recognized as a valuable feature in image analysis, particularly in the field of medical imaging. Our proposed method extends the two-dimensional approach of the Slope Chain Code (SCC) which creates a one-dimensional representation of curves. The utility of 3D tortuosity ( $$\tau _{3D}$$ τ 3 D ) as a shape descriptor was investigated by characterizing brain structures. The results of the $$\tau _{3D}$$ τ 3 D computation on the central sulcus and the main lobes revealed significant differences between Alzheimer’s disease (AD) patients and control subjects, suggesting its potential as a biomarker for AD. We found a $$p
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