Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement

Autor: Anami Ahuja, Pankaj Kumar Tyagi, Manoj Kumar, Naveen Sharma, Suraj Prakash, Radha, Deepak Chandran, Sangram Dhumal, Nadeem Rais, Surinder Singh, Abhijit Dey, Marisennayya Senapathy, Lejaniya Abdul Kalam Saleena, Arjun Shanavas, Pran Mohankumar, Sureshkumar Rajalingam, Yasodha Murugesan, Marthandan Vishvanathan, Sangeetha Kizhakkumkara Sathyaseelan, Sabareeshwari Viswanathan, Keerthana Krishna Kumar, Suman Natta, Mohamed Mekhemar
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cells, Vol 11, Iss 18, p 2792 (2022)
Druh dokumentu: article
ISSN: 11182792
2073-4409
DOI: 10.3390/cells11182792
Popis: Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells. In recent years, several studies have reported that plant extracts or compounds promoted the proliferation, differentiation, and survival of different oral stem cells. This review is carried out by following the PRISMA guidelines and focusing mainly on the effects of bioactive compounds on oral stem cell-mediated dental, bone, and neural regeneration. It is observed that in recent years studies were mainly focused on the utilization of oral stem cell-mediated regeneration of bone or dental mesenchymal cells, however, the utility of bioactive compounds on oral stem cell-mediated regeneration requires additional assessment beyond in vitro and in vivo studies, and requires more randomized clinical trials and case studies.
Databáze: Directory of Open Access Journals
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