Thioredoxin 2 protects mice against experimental myocardial infarction

Autor:	Tania Medali, Dominique Couchie, Nathalie Mougenot, Maria Mihoc, Olaf Bergmann, Wouter Derks, Celio X Santos, Bertrand Friguet, Mustapha Rouis
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	myocardial infarction heart failure thioredoxin 2 Physiology QP1-981 Therapeutics. Pharmacology RM1-950
Zdroj:	Redox Experimental Medicine, Vol 2024, Iss 1, Pp 1-8 (2024)
Druh dokumentu:	article
ISSN:	2755-158X
DOI:	10.1530/REM-23-0029
Popis:	Experimental Myocardial infarction (MI) using ligation procedure induces cardiac dysfunction, high level of ROS, inflammation, apoptosis, fibrosis and cardiomyocyte (CM) loss. AAV overexpressing human Trx-2, specifically in CM mitochondria improves mouse cardiac function, reduces the size of cardiac infarct, increases the expression of cardiac anti-inflammatory markers, reduces apoptosis and oxidative stress. However, it does not increase CM proliferation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1cd120feb088402083b549d271f3db62 Zobrazit plný text záznamu View record in DOAJ