Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

Autor: Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29150-6
Popis: Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with aging.
Databáze: Directory of Open Access Journals