Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer

Autor: Vidic Zala, Goricar Katja, Strazisar Branka, Besic Nikola, Dolzan Vita
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Radiology and Oncology, Vol 57, Iss 1, Pp 111-120 (2023)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2023-0003
Popis: Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miRNA genes with outcomes of tramadol/paracetamol treatment after breast cancer surgery with axillary lymphadenectomy.
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