| Autor: |
Renata A.P. Sakata, Rodrigo Cayô da Silva, Ana C. Gales, Gabriel T. Cuba, Antonio C.C. Pignatari, Carlos R.V. Kiffer |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Global Antimicrobial Resistance, Vol 28, Iss , Pp 115-119 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2213-7165 |
| DOI: |
10.1016/j.jgar.2021.10.031 |
| Popis: |
ABSTRACT: Objectives: Consumption trends of four broad-spectrum antimicrobials and their correlation with antimicrobial resistance in Gram-negative bacilli (GNB) from 2013–2017 within intensive care units (ICUs) were explored. Methods: Consumption of meropenem (MEM), polymyxin B (PMB), piperacillin/tazobactam (TZP) and cefepime (FEP) in defined daily doses per 1000 patient-days (DDD/1000PD) was measured. Infection-related GNB isolates were grouped according to specific resistance profiles. Time series of antimicrobial consumption and their parametric correlation with each grouped resistant GNB were explored. Results: A total of 1423 GNB were evaluated. A significant linear decline in consumption was observed for MEM [slope –3.88, 95% confidence interval (CI) –4.96 to –2.81; P < 0.0001] and PMB (slope –3.51, 95% CI –5.528 to –1.495; P = 0.0009). A significant decline in MEM-non-susceptible Acinetobacter spp. (R2 = 0.476; P = 0.006) and an increase in FEP-non-susceptible Escherichia coli (R2 = 0.124; P = 0.006) was observed. A significant correlation between MEM consumption and MEM-non-susceptible Acinetobacter spp. (r = 0.43; P = 0.001) was observed. MEM consumption and MEM-non-susceptible Acinetobacter spp. showed a positive correlation. Conclusion: Reduction in the consumption of broad-spectrum antimicrobials may alter the frequency of infection-related isolates and their antimicrobial resistance profiles. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full Text from ScienceDirect