| Autor: |
Rajani Kanteti, Immanuel Dhanasingh, Ichiro Kawada, Frances E Lennon, Qudsia Arif, Raphael Bueno, Rifat Hasina, Aliya N Husain, Wickii Vigneswaran, Tanguy Seiwert, Hedy L Kindler, Ravi Salgia |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 9, p e105919 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0105919 |
| Popis: |
Malignant pleural mesothelioma (MPM) is an aggressive disease with a poor prognosis. Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. Here we determined the combinatorial therapeutic efficacy of a new generation small molecule inhibitor of MET, ARQ 197, and dual PI3K/mTOR inhibitors NVP-BEZ235 and GDC-0980 in mesothelioma cell and mouse xenograft models. Cell viability results show that mesothelioma cell lines were sensitive to ARQ 197, NVP-BEZ235 and GDC-0980 inhibitors. The combined use of ARQ 197 with either NVP-BEZ235 or GDC-0980, was synergistic (CI |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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