Evaluation of protein C and S levels in patients with COVID-19 infection and their relation to disease severity

Autor: Ahmed Elshafie, Enas Foda, Mahmoud M. G. Yousef, Kareem A. Abd El-Naby
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Egyptian Journal of Internal Medicine, Vol 35, Iss 1, Pp 1-5 (2023)
Druh dokumentu: article
ISSN: 2090-9098
DOI: 10.1186/s43162-023-00195-3
Popis: Abstract Background The COVID-19 pandemic has been associated with millions of deaths around the world. One of the important causes of death associated with COVID-19 was pulmonary thromboembolism. The risk for venous thromboembolism was markedly increased in patients with COVID-19 especially those admitted to the intensive care unit. The aims of our study were to measure the protein C and S levels in COVID-19-infected patients in comparison with the normal population and to assess the correlation of protein C and S levels in the plasma to the severity of infection. Methods This was a case–control study measuring the protein C and S levels in patients infected with COVID-19 at the time of diagnosis compared to the normal population. The study included one hundred participants, sixty of them are patients with COVID-19, and forty of them are normal healthy adults. The patient group was subclassified into three subgroups according to disease severity: mild, moderate, and severe COVID-19 infections. Results The activity of protein C in the patient group serum was significantly lower than that in the control group serum (79.35 ± 26.017 vs 97.43 ± 15.007; p
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