| Autor: |
Xue Zhang, Qifei Deng, Zhini He, Jie Li, Xiaoju Ma, Zhaorui Zhang, Dehua Wu, Xiumei Xing, Jing Peng, Hongyu Guo, Ming Huang, Liping Chen, Shanfeng Dang, Yanqun Zhu, Zhengbao Zhang, Boyi Yang, Hailan Wang, Wen Chen, Yongmei Xiao |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BMC Public Health, Vol 20, Iss 1, Pp 1-13 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2458 |
| DOI: |
10.1186/s12889-020-08493-z |
| Popis: |
Abstract Background Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG), and occurrence of fatty liver. Results The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) (P-overall |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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