| Autor: |
C. Rahila, M.B. Aswath Narayanan, S.G. Ramesh Kumar, A. Leena Selvamary, A. Sujatha, J. John Kirubaharan |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Saudi Dental Journal, Vol 31, Iss 4, Pp 463-468 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1013-9052 |
| DOI: |
10.1016/j.sdentj.2019.05.004 |
| Popis: |
Introduction: Dental fluorosis is a foremost public health problem in many countries, including India. Very few studies investigated gene polymorphism and risk of dental fluorosis. Genetic polymorphisms in Collagen Type I, alpha 2 (COL1A2) gene, found to be linked with bone pathogenesis, may affect the tooth formation resulting in the vulnerability to dental fluorosis. Aim: To assess the association between COL1A2 (PvuII) gene polymorphism and risk as well as severity of dental fluorosis. Methods: The present case control study was conducted among participants with (n = 60) and without (n = 60) dental fluorosis. Dental fluorosis was assessed using Modified Dean’s fluorosis index (1942). The PvuII polymorphisms (in exon 25) inside the COL1A2 gene were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) procedure. Statistical analysis were carried out with Chi-square test and Odds Ratio (OR) was determined with multivariate logistic regression analysis. Results: The genetic polymorphism in COL1A2 PvuII was found to be associated with the risk of dental fluorosis which was highly significant (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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