Clinical Parameters and Outcomes of Biliary Atresia in Children: A Single Centre Study

Autor: Raazia Nawaz, Farooq Ikram, Bilal, Saba Idrees, Ifnan Shamraiz, Samina Tabassum
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Pakistan Armed Forces Medical Journal, Vol 74, Iss 4 (2024)
Druh dokumentu: article
ISSN: 0030-9648
2411-8842
DOI: 10.51253/pafmj.v74i4.9280
Popis: Objective: To assess the clinical and laboratory parameters, interventions and their outcomes in children presenting with biliary atresia at a tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of study: Pediatric Gastroenterology and Hepatology Department of Combined Military Hospital, Rawalpindi Pakistan, from Feb 2021 to Jan 2022. Methodology: Patients diagnosed with extrahepatic biliary atresia on the basis of liver histopathology and intra operative cholangiogram were enrolled consecutively during this period. The clinical parameters, liver function tests, radiological investigations and histopathology findings were recorded and correlated. The impact of Kasai procedure on outcome and prognosis of biliary atresia patients was noted along with an interval analysis at 1 year of age. Results: Forty patients were studied including 26 males and 14 females. Thirty (75%) patients underwent Kasai at a median age of 3.14±1.2 months with a success rate of 66.6% (p-value0.05). A statistically significant relation was established between one-year outcomes of patients undergoing Kasai Hepatic Portoenterostomy and without Kasai Hepatic Portoenterostomy (p-value 0.01). A significant difference in survival of patients undergoing Kasai Hepatic Portoenterostomy and those without Kasai Hepatic Portoenterostomy (p< 0.001) was observed. Conclusion: Intervention in the form of Kasai Hepatic Portoenterostomy significantly contributes towards an improved outcome in patients with Biliary Atresia.
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