| Autor: |
Francesca Fumagalli, Davide Olivari, Antonio Boccardo, Daria De Giorgio, Roberta Affatato, Sabina Ceriani, Simone Bariselli, Giulia Sala, Alberto Cucino, Davide Zani, Deborah Novelli, Giovanni Babini, Aurora Magliocca, Ilaria Russo, Lidia Staszewsky, Monica Salio, Jacopo Lucchetti, Antonio Marco Maisano, Fabio Fiordaliso, Roberto Furlan, Marco Gobbi, Mario Vittorio Luini, Davide Pravettoni, Eugenio Scanziani, Angelo Belloli, Roberto Latini, Giuseppe Ristagno |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 24 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.120.016494 |
| Popis: |
Background Ventilation with the noble gas argon (Ar) has shown neuroprotective and cardioprotective properties in different in vitro and in vivo models. Hence, the neuroprotective effects of Ar were investigated in a severe, preclinically relevant porcine model of cardiac arrest. Methods and Results Cardiac arrest was ischemically induced in 36 pigs and left untreated for 12 minutes before starting cardiopulmonary resuscitation. Animals were randomized to 4‐hour post‐resuscitation ventilation with: 70% nitrogen–30% oxygen (control); 50% Ar–20% nitrogen–30% oxygen (Ar 50%); and 70% Ar–30% oxygen (Ar 70%). Hemodynamic parameters and myocardial function were monitored and serial blood samples taken. Pigs were observed up to 96 hours for survival and neurological recovery. Heart and brain were harvested for histopathology. Ten animals in each group were successfully resuscitated. Ninety‐six‐hour survival was 60%, 70%, and 90%, for the control, Ar 50%, and Ar 70% groups, respectively. In the Ar 50% and Ar 70% groups, 60% and 80%, respectively, achieved good neurological recovery, in contrast to only 30% in the control group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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