| Autor: |
Mitchell Tyler, MS, Kim Skinner, DPT, Vivek Prabhakaran, MD, PhD, Kurt Kaczmarek, PhD, Yuri Danilov, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Archives of Rehabilitation Research and Clinical Translation, Vol 1, Iss 3, Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1095 |
| DOI: |
10.1016/j.arrct.2019.100026 |
| Popis: |
Objective: To compare the efficacy of high- and low-frequency noninvasive translingual neurostimulation (TLNS) plus targeted physical therapy (PT) for treating chronic balance and gait deficits due to mild-to-moderate traumatic brain injury (mmTBI). Design: Participants were randomized 1:1 in a 26-week double-blind phase 1/2 study (NCT02158494) with 3 consecutive treatment stages: in-clinic, at-home, and no treatment. Arms were high-frequency pulse (HFP) and low-frequency pulse (LFP) TLNS. Setting: TLNS plus PT training was initiated in-clinic and then continued at home. Participants: Participants (N=44; 18-65y) from across the United States were randomized into the HFP and LFP (each plus PT) arms. Forty-three participants (28 women, 15 men) completed at least 1 stage of the study. Enrollment requirements included an mmTBI ≥1 year prior to screening, balance disorder due to mmTBI, a plateau in recovery with current PT, and a Sensory Organization Test (SOT) score ≥16 points below normal. Interventions: Participants received TLNS (HFP or LFP) plus PT for a total of 14 weeks (2 in-clinic and 12 at home), twice daily, followed by 12 weeks without treatment. Main Outcome Measures: The primary endpoint was change in SOT composite score from baseline to week 14. Secondary variables (eg, Dynamic Gait Index [DGI], 6-minute walk test [6MWT]) were also collected. Results: Both arms had a significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
