A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class

Autor:	Kelly N. Hallstrom, Gwendowlyn S. Knapp
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	immunology laboratory remote learning activities tactile learning undergraduate immunology V(D)J recombination Special aspects of education LC8-6691 Biology (General) QH301-705.5
Zdroj:	Journal of Microbiology & Biology Education, Vol 24, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	1935-7885 1935-7877
DOI:	10.1128/jmbe.00145-22
Popis:	ABSTRACT This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene segments and recombination signal sequences. Students are provided with instructions for using the pipe cleaners to assemble specific light and heavy immunoglobulin chains. Students each assemble their own light and heavy chains and compare the products made by classmates. This activity uses materials that are easy and affordable to acquire and provides a tactile approach to reinforcing concepts that students often struggle to visualize and master from lecture and textbook material alone.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1c82d442da8e42e3b3e414fdb509c314 Zobrazit plný text záznamu View record in DOAJ