Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets

Autor: Ferdinand H. Lutter, Lucie Grokenberger, Luca Alessandro Perego, Diego Broggini, Sébastien Lemaire, Simon Wagschal, Paul Knochel
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18188-z
Popis: Aryl azoles are common scaffolds in pharmaceutically relevant molecules. Here, the authors report the mild and highly regioselective ortho magnesiation of aryl azoles using a tailored magnesium amide base in hydrocarbon solvents followed by an efficient Pd-catalyzed arylation.
Databáze: Directory of Open Access Journals