Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies

Autor:	Carme Fàbrega, Anna Aviñó, Natalia Navarro, Andreia F. Jorge, Santiago Grijalvo, Ramon Eritja
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	antisense oligonucleotides siRNA lipid-oligonucleotide conjugates peptide-oligonucleotide conjugates Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 15, Iss 2, p 320 (2023)
Druh dokumentu:	article
ISSN:	15020320 1999-4923
DOI:	10.3390/pharmaceutics15020320
Popis:	Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up into tissues and are susceptible to degradation by nucleases. For these reasons, the design and preparation of modified DNA/RNA derivatives with better stability and an ability to be produced at large scale with enhanced uptake properties is of vital importance to improve current limitations. In the present study, we review the conjugation of oligonucleotides with lipids and peptides in order to produce oligonucleotide conjugates for therapeutics aiming to develop novel compounds with favorable pharmacokinetics.
Databáze:	Directory of Open Access Journals
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