PROPHYLACTIC AND THERAPEUTIC EFFICACY OF THE POLYVALENT PYOBACTERIOPHAGE IN THE TREATMENT OF ACUTE DESTRUCTIVE PANCREATITIS
| Autor: | V. P. Nikulina, Z. M. Ozova, M. A. Godkov |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Неотложная медицинская помощь, Vol 0, Iss 3, Pp 35-41 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2223-9022 2541-8017 |
| Popis: | BACKGROUND. The high mortality in severe acute pancreatitis is mainly assoociated with septic complications developing during translocation of intestinal potentially pathogenic flora into the initially sterile necrosis.AIMOFSTUDy. To determine the prophylactic and therapeutic effect of polyvalent pyobacteriophage (PBP) included into the complex treatment of acute destructive pancreatitis to reduce the rate of infectious complications and mortality. MATERIALANDMETHODS. The study included 38 patients admitted to the N.V. Sklifosovsky Research Institute for Emergency Medicine with acute destructive pancreatitis and pancreatic necrosis. All patients underwent the standard therapy. In patients of group 1 (N=13), PBP was included into treatment in the first 2 weeks after admission (2–15 day). In patients of group 2 (N=12), the bacteriophage was used during septic complications (16–60 hours). The comparison group consisted of patients not receiving PBP in the course of treatment. The activity of the inflammatory process over time was evaluated by the level of C-reactive protein (CRP). The marker of systemic inflammation was procalcitonin (PCT). We performed immunology tests: the number of leucocytes, lymphocytes (Tand B-lymphocytes), phagocytic activity and oxygen metabolism of neutrophils in the HCT-test, concentration of immunoglobulin A, M, G, circulating immune complexes (CICs) before and after PBP.RESULTS. It was found that the earlier use of PBP had helped reduce inflammation and areas of intoxication, which was manifested by a fall of CRP and PCT (p |
| Databáze: | Directory of Open Access Journals |
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