Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs

Autor: Taesik Yun, Yoonhoi Koo, Yeon Chae, Dohee Lee, Hakhyun Kim, Soochong Kim, Dongwoo Chang, Ki‐Jeong Na, Mhan‐Pyo Yang, Byeong‐Teck Kang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 35, Iss 4, Pp 1865-1872 (2021)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16184
Popis: Abstract Background Neurofilament light chain (NfL) is a neuron‐specific cytoskeletal protein expressed in axons. Damaged axons of the central nervous system release NfLs into the cerebrospinal fluid (CSF) and the blood. In humans with neurologic diseases, NfL is used as a biomarker. Objectives To identify the potential of NfL as a supportive tool for the diagnosis, prognosis, and monitoring of meningoencephalitis of unknown etiology (MUE) in dogs. Animals Twenty‐six client‐owned healthy dogs, 10 normal Beagle dogs, and 38 client‐owned MUE dogs. Methods Cohort study. The concentrations of NfL in serum and CSF were measured using single‐molecule array technology. Results Median NfL concentration was significantly higher in MUE dogs (serum, 125 pg/mL; CSF, 14 700 pg/mL) than in healthy dogs (serum, 11.8 pg/mL, P
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