| Autor: |
Dawn M Dudley, Michelle R Koenig, Laurel M Stewart, Matthew R Semler, Christina M Newman, Phoenix M Shepherd, Keisuke Yamamoto, Meghan E Breitbach, Michele Schotzko, Sarah Kohn, Kathleen M Antony, Hongyu Qiu, Priyadarshini Tunga, Deborah M Anderson, Wendi Guo, Maria Dennis, Tulika Singh, Sierra Rybarczyk, Andrea M Weiler, Elaina Razo, Ann Mitzey, Xiankun Zeng, Jens C Eickhoff, Emma L Mohr, Heather A Simmons, Michael K Fritsch, Andres Mejia, Matthew T Aliota, Thomas C Friedrich, Thaddeus G Golos, Shantha Kodihalli, Sallie R Permar, David H O'Connor |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 17, Iss 7, p e0266664 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0266664 |
| Popis: |
There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
