| Autor: |
Md. Rezuan Al Mahmud, Md. Mahmudul Hasan, Dipa Roy, Md. Sk Shahid Ullah, Bristy Basak, Md. Abu Reza, Ariful Haque |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Advanced Biotechnology and Experimental Therapeutics, Vol 4, Iss 1, Pp 60-66 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2616-4760 |
| DOI: |
10.5455/jabet.2021.d107 |
| Popis: |
Tumor necrosis factor-alpha (TNF-α) is a major cytokine for inflammatory response in human body. This is also well linked with obesity and causing different pathophysiological problems in type 2 diabetic mellitus (T2DM) patients because of its pro-inflammatory over expression. However, seemingly harmless nucleotide changes in the promoter region often cause oscillation in expression, results in complications like dyslipidemia and atherosclerosis that ultimately exploit to coronary heart disease (CHD). Therefore, this study was designed to evaluate association between TNF-α (-308G>A) polymorphism at promoter region and CHD in T2DM patients from the northern region (Rajshahi) of Bangladesh. The total number of participants was 96 T2DM patients. TNF-α polymorphism were detected using high resolution melting (HRM) curve analysis. A total of 32 participants were suffering from CHD and 8 polymorphism (3 homozygous and 5 heterozygous) were detected among them. From Fishers Exact test, we found significant (P < 0.05) relationship between TNF-α polymorphism and CHD in T2DM patients. According to Kendalls Tau correlation matrix (r = 0.218), there is a good correlation between polymorphism and CHD. Therefore, the overall results suggest that TNF-α (-308G>A) polymorphism is responsible for inducing CHD in T2DM patients. [ J Adv Biotechnol Exp Ther 2021; 4(1.000): 60-66] |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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