Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey

Autor: Natalia Yurievna Pshenichnaya, Hakan Leblebicioglu, Ilkay Bozkurt, Irina Viktorovna Sannikova, Gulzhan Narkenovna Abuova, Andrey Sergeevich Zhuravlev, Sener Barut, Mutabar Bekovna Shermetova, Tom E. Fletcher
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 58, Iss C, Pp 58-64 (2017)
Druh dokumentu: article
ISSN: 1201-9712
1878-3511
DOI: 10.1016/j.ijid.2017.02.019
Popis: Background: Crimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood. Objectives: To systematically review the characteristics of CCHF in pregnancy, and report a case series of 8 CCHF cases in pregnant women from Russia, Kazakhstan and Turkey. Methods: A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. PubMed, SCOPUS, Science Citation Index (SCI) were searched for reports published between January 1960 and June 2016. Two independent reviewers selected and reviewed studies and extracted data. Results: Thirty-four cases of CCHF in pregnancy were identified, and combined with the case series data, 42 cases were analyzed. The majority of cases originated in Turkey (14), Iran (10) and Russia (6). There was a maternal mortality of 14/41(34%) and fetal/neonatal mortality of in 24/41 cases (58.5%). Hemorrhage was associated with maternal (p = 0.009) and fetal/neonatal death (p
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