Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women
| Autor: | Mehdi Sahmani, Nilofar Ahmadi, Somayeh Asadian, Talaat Dabaghi Ghaleh, Amir Javadi |
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| Jazyk: | perština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Journal of Qazvin University of Medical Sciences, Vol 24, Iss 5, Pp 434-443 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1561-3666 2228-7213 |
| DOI: | 10.32598/JQUMS.24.5.6 |
| Popis: | Background Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results. Objective This study aims to investigate the possible association between rs3918242 (−1562C>T) polymorphism in Matrix Metalloproteinase 9 (MMP9) gene with the risk of preeclampsia in pregnant women. Methods In this cross-sectional study, participants were 90 pregnant women with preeclampsia and 199 healthy pregnant women (controls). The genotypes of rs3918242 polymorphism were investigated using Polymerase Chain Reaction technique and Limited Fragment Length Polymorphism method. Logistic regression analysis was used to investigate the relationship between rs3918242 polymorphism and preeclampsia. Findings The frequency of CC, CT, TT genotypes of rs3918242 polymorphism was reported 47.8%, 47.8% and 4.2% in patients and 84.8, 13.1 and 2% in controls, respectively, and the difference between groups was significant (P |
| Databáze: | Directory of Open Access Journals |
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