Cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban national immunization programme

Autor: Anai García Fariñas, Nivaldo Linares-Pérez, Andrew Clark, María Eugenia Toledo-Romaní, Nathalie El Omeiri, Martha C. Marrero Araújo, Isabel Pilar Gonzálvez Luis, Gilda Toraño Peraza, Alicia Reyes Jiménez, Lena López Ambrón
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 97, Iss , Pp 182-189 (2020)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2020.05.078
Popis: Objectives: To evaluate the cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban National Immunization Program (NIP). Methods: We compared PCV7-TT given at two, four and six months of age to a scenario without PCV7-TT, over a ten-year period (2020–2029). We calculated the cost (Cuban pesos – CUP) per Disability Adjusted Life Year (DALY) averted from a Government perspective. We compared results from a static cohort model and a parsimonious prediction model informed by the serotype distribution among pneumococcal carriers and cases. We ran probabilistic and deterministic uncertainty analyses. Results: PCV7-TT could prevent 6897 (95% uncertainty interval, 4344–8750) hospitalizations and 189 (115–253) deaths in children
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