Blood microbiota in HIV-infected and HIV-uninfected patients with suspected sepsis detected by metagenomic next-generation sequencing

Autor:	Qianhui Chen, Zhong Chen, Yuting Tan, Songjie Wu, Shi Zou, Jie Liu, Shihui Song, Qian Du, Min Wang, Ke Liang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Metagenomic next-generation sequencing Human immunodeficiency virus Suspected sepsis Blood microbiota Infectious and parasitic diseases RC109-216
Zdroj:	BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	1471-2334
DOI:	10.1186/s12879-024-10009-8
Popis:	Abstract Background Information on the comparison of blood microbiota between human immunodeficiency virus (HIV)-infected and HIV-uninfected patients with suspected sepsis by metagenomic next-generation sequencing (mNGS) is limited. Methods Retrospectively analysis was conducted in HIV-infected and HIV-uninfected patients with suspected sepsis at Changsha First Hospital (China) from March 2019 to August 2022. Patients who underwent blood mNGS testing were enrolled. The blood microbiota detected by mNGS were analyzed. Results A total of 233 patients with suspected sepsis who performed blood mNGS were recruited in this study, including 79 HIV-infected and 154 HIV-uninfected patients. Compared with HIV-uninfected patients, the proportions of mycobacterium (p = 0.001), fungus (p
Databáze:	Directory of Open Access Journals
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