| Autor: |
Yanhua Wang, Ting Wang, Mengmeng Xu, Haitao Yu, Chunguang Ding, Zhenjie Wang, Xingfu Pan, Yanbo Li, Yong Niu, Ruixue Yan, Jiayang Song, Huifang Yan, Yufei Dai, Zhiwei Sun, Wenge Su, Huawei Duan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Environment International, Vol 134, Iss , Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0160-4120 |
| DOI: |
10.1016/j.envint.2019.105296 |
| Popis: |
Background: There is a paucity of mechanistic information on the DNA methylation and particulate matter (PM) exposure. This study aimed to investigate the association of PM and its component with DNA methylation, and the roles of DNA methyltransferase (DNMTs). Methods: There were 240 high-exposed, 318 low-exposed and 210 non-exposed participants in this study. Individual concentrations of PM, polycyclic aromatic hydrocarbons (PAHs) and metals were identified by the monitoring data in their workplaces. Urinary 1-OHP and metals were determined as exposure markers. The global DNA methylation (% 5mC) and the mRNA expression of DNMT1, DNMT3A and DNMT3B were measured. We used mediation analysis to evaluate the role of DNMTs expression on DNA methylation alteration induced by PAHs and metals components. Results: The decreasing trend of % 5mC was associated with increment of PM exposure in all subjects. We found that one IQR increase in total PAHs (3.82 μg/m3) and urinary 1-OHP (1.06 μmol/mol creatinine) were associated with a separate 6.08% and 7.26% decrease in % 5mC (P = 0.009, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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