Serum Paraoxonase-Early Diagnostic Biomarker in NASH/NAFLD
| Autor: | Jyotchna Devi Bade, Kiranmai Chittajallu, Naazia Arifuddin, Thejaswini Muppala, Balachandrarao Naidu Menda, Uma Lakshmi Valluri |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 13, Iss 10, Pp BC06-BC09 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2019/42414.13220 |
| Popis: | Introduction: Non-Alcoholic Steatohepatitis (Nash)/NonAlcoholic Fatty Liver Disease (NAFLD) is one of the important causes of morbidity and mortality worldwide. Serum paraoxonase (PON 1) is a glycosylated protein, an esterase associated with High density lipoprotein (HDL), and can be speculated to be a potential biomarker of liver injury or lipid peroxidation. Aim: To assess the PON 1activity in NASH/NAFLD in combination with standard liver function tests in evaluating liver damage. Materials and Methods: The case-control study was conducted at Department of Biochemistry, Osmania General Hospital, Hyderabad, India. Serum Paraoxonase levels were estimated in 30 clinically diagnosed NASH/NAFLD patients, and 30 apparently healthy blood donors. Serum Paraoxonase levels was measured by kinetic assay in spectrophotometer along with standard liver function tests (total and direct bilirubin, total protein, albumin, Alanine Transaminase (AST), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP). Results were expressed as Mean±Standard deviation (Mean±SD) of various parameters. Paired t-test was used to compare the parameters between control and case group. ROC curve analysis was done to assess maximum sensitivity and maximum specificity and diagnostic efficiency. A p-value of |
| Databáze: | Directory of Open Access Journals |
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