Synthesis of Substituted Pyrido-oxazine through Tandem SN2 and SNAr Reaction

Autor: Mosim Amin Pathan, Faiz Ahmed Khan
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: SynOpen, Vol 02, Iss 02, Pp 0150-0160 (2018)
Druh dokumentu: article
ISSN: 2509-9396
DOI: 10.1055/s-0036-1591960
Popis: Abstract Pyrido-oxazine derivatives have been synthesized by employing tandem SN2 and SNAr reaction between 2,4,6-tribromo-3-(2-bromoethoxy)pyridine or 2,4,6-tribromo-3-(3-bromopropoxy)pyridine and a variety of primary amines. Moderate to good regioselectivity in favor of cyclization at the 2-position is observed. Pyrido-oxazine products thus generated are converted into biarylated pyrido-oxazine and terpyridine ligands.
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