| Autor: |
Melise Chaves Silveira, Cláudio Marcos Rocha-de-Souza, Ivson Cassiano de Oliveira Santos, Leilane da Silva Pontes, Thamirys Rachel Tavares e Oliveira, Camila Bastos Tavares-Teixeira, Nataly de Almeida Cossatis, Natacha Ferreira Pereira, Orlando Carlos da Conceição-Neto, Bianca Santos da Costa, Daiana Cristina Silva Rodrigues, Rodolpho Mattos Albano, Fabrício Alves Barbosa da Silva, Elizabeth Andrade Marques, Robson Souza Leão, Ana Paula D'Alincourt Carvalho-Assef |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 8 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2021.635206 |
| Popis: |
Multidrug-resistant microorganisms are a well-known global problem, and gram-negative bacilli are top-ranking. When these pathogens are associated with bloodstream infections (BSI), outcomes become even worse. Here we applied whole-genome sequencing to access information about clonal distribution, resistance mechanism diversity and other molecular aspects of gram-negative bacilli (GNB) isolated from bloodstream infections in Brazil. It was possible to highlight international high-risk clones circulating in the Brazilian territory, such as CC258 for Klebsiella pneumoniae, ST79 for Acinetobacter baumannii and ST233 for Pseudomonas aeruginosa. Important associations can be made such as a negative correlation between CRISPR-Cas and K. pneumoniae CC258, while the genes blaTEM, blaKPC and blaCTX−M are highly associated with this clone. Specific relationships between A. baumannii clones and blaOXA−51 variants were also observed. All P. aeruginosa ST233 isolates showed the genes blaVIM and blaOXA486. In addition, some trends could be identified, where a new P. aeruginosa MDR clone (ST3079), a novel A. baumannii clonal profile circulating in Brazil (ST848), and important resistance associations in the form of blaVIM−2 and blaIMP−56 being found together in one ST233 strain, stand out. Such findings may help to develop approaches to deal with BSI and even other nosocomial infections caused by these important GNB. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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