| Autor: |
Arif Siddiqui |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Al Ameen Journal of Medical Sciences, Vol 01, Iss 01, Pp 32-41 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
0974-1143 |
| Popis: |
Developmental exposure with diazepam when coinciding with the ontogenesis of its receptors may be crucial for the induction of long-term functional disturbances in the rat brain. To investigate the possibility of intervention in the sexually dimorphic behavior of reproduction and the under lying morphological and hormonal basis the time-mated female rats were treated with 2.5 mg/kg, 5 mg/kg and 10 mg/kg, i.p.(n = 6-8) separately. Treatment was continued from gestation day 15 till delivery and further continued to neonates 5 days, postnatally. Control group (n= 5-8) given saline also followed the same treatment protocol. Sexual behavior in the male offspring at adulthood born to diazepam-exposed rats was enhanced, both in dose-dependent and time-dependent manner (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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