A Dynamic Model of PI3K/AKT Pathways in Acute Myeloid Leukemia

Autor: Yudi Ari Adi, Fajar Adi-Kusumo, Lina Aryati, Mardiah S. Hardianti
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Applied Mathematics, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1110-757X
1687-0042
DOI: 10.1155/2018/2983138
Popis: Acute myeloid leukemia (AML) is a malignant hematopoietic disorder characterized by uncontrolled proliferation of immature myeloid cells. In the AML cases, the phosphoinositide 3-kinases (PI3K)/AKT signaling pathways are frequently activated and strongly contribute to proliferation and survival of these cells. In this paper, a mathematical model of the PI3K/AKT signaling pathways in AML is constructed to study the dynamics of the proteins in these pathways. The model is a 5-dimensional system of the first-order ODE which describes the interaction of the proteins in AML. The interactions between those components are assumed to follow biochemical reactions, which are modelled by Hill’s equation. From the numerical simulations, there are three potential components targets in PI3K/AKT pathways to therapy in the treatment of AML patient.
Databáze: Directory of Open Access Journals
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