Juvenile Localized Scleroderma. Questions of Treatment

Autor:	Rinat K. Raupov, Mikhail M. Kostik
Jazyk:	English<br />Russian
Rok vydání:	2020
Předmět:	juvenile localized scleroderma morphea linear morphea topical glucocorticosteroids tacrolimus methotrexat mycophenolate mofetil genetically engineered biologic drugs Pediatrics RJ1-570
Zdroj:	Вопросы современной педиатрии, Vol 19, Iss 3, Pp 228-234 (2020)
Druh dokumentu:	article
ISSN:	1682-5527 1682-5535
DOI:	10.15690/vsp.v19i3.2119
Popis:	Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS. The JLS treatment during active phase (when skin lesions are reversible) is the most effective. The management is determined by the area and depth of skin lesions, appearance and spread of new lesions, presence of extracutaneous signs of the disease. Topical and systemic immunosuppressants are the basic therapy for JLS. The use of antibiotics is not suggested. Clinical scores (LoSCAT), ultrasound, thermography and magnetic resonance imaging are recommended to estimate the treatment efficacy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1bc923dffbd04b648aa9d7ad46800a0d Zobrazit plný text záznamu View record in DOAJ