| Autor: |
Vergara Daniele, Simeone Pasquale, Julien Frank, Trerotola Marco, Giudetti Anna, Capobianco Loredana, Tinelli Andrea, Bellomo Claudia, Fournier Isabelle, Antonio Gaballo, Alberti Saverio, Salzet Michel, Maffia Michele |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
EuPA Open Proteomics, Vol 10, Iss C, Pp 31-41 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2212-9685 |
| DOI: |
10.1016/j.euprot.2016.01.003 |
| Popis: |
The growing understanding of the molecular mechanisms underlying epithelial-to-mesenchymal transition (EMT) may represent a potential source of clinical markers. Despite EMT drivers have not yet emerged as candidate markers in the clinical setting, their association with established clinical markers may improve their specificity and sensitivity. Mass spectrometry-based platforms allow analyzing multiple samples for the expression of EMT candidate markers, and may help to diagnose diseases or monitor treatment efficiently. This review highlights proteomic approaches applied to elucidate the differences between epithelial and mesenchymal tumors and describes how these can be used for target discovery and validation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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