| Autor: |
Dr. Yui Sasaki, Kohei Ohshiro, Miyuki Kato, Dr. Daijiro Haba, Prof. Dr. Gojiro Nakagami, Prof. Dr. Tsuyoshi Minami |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
ChemElectroChem, Vol 11, Iss 19, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2196-0216 |
| DOI: |
10.1002/celc.202400292 |
| Popis: |
Abstract Sweat glucose serves as a significant biomarker of health, necessitating accurate determination at the micromolar level for noninvasive monitoring. To address this need, we design an organic field‐effect transistor (OFET)‐based enzymatic sensor to quantify glucose levels in human sweat. The extended‐gate structure of the OFET device ensures stable analyte detection in human sweat owing to its isolated configuration. The extended‐gate‐type OFET has been functionalized with glucose oxidase and an N‐ethylphenazonium‐based mediator‐attached monolayer. This configuration facilitates electron relay, enabling accurate and reproducible glucose detection. Leveraging the amplification ability of the OFET, the enzymatic sensor exhibited highly sensitive glucose detection, achieving a low limit of detection (2.9 μM) suitable for sweat analysis requirements. In addition, the sensor exhibited high discriminability in detecting glucose amidst interferents commonly found in sweat, indicating its practical feasibility for sweat analysis. Validation of glucose recovery rates (95–105 %) in human sweat, without pretreatment, was performed using established instrumental analysis methods. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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