Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents

Autor:	Shangjun Chen, Lu An, Shiping Yang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Fe(III) complexes MRI contrast agents relaxivity thermodynamic stability structure relationship Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 14, p 4573 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27144573
Popis:	Fe(III) complexes have again attracted much attention for application as MRI contrast agents in recent years due to their high thermodynamic stability, low long-term toxicity, and large relaxivity at a higher magnetic field. This mini-review covers the recent progress on low-molecular-weight Fe(III) complexes, which have been considered as one of the promising alternatives to clinically used Gd(III)-based contrast agents. Two kinds of complexes including mononuclear Fe(III) complexes and multinuclear Fe(III) complexes are summarized in sequence, with a specific highlight of the structural relationships between the complexes and their relaxivity and thermodynamic stability. In additional, the future perspectives for the design of low-molecular-weight Fe(III) complexes for MRI contrast agents are suggested.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a1bab2ae98284062a096cd3e81a10333 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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