Natural killer cell subset count and antigen‐stimulated activation in response to exhaustive running following adaptation to a ketogenic diet

Autor: David M. Shaw, Lauren Keaney, Ed Maunder, Deborah K. Dulson
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Experimental Physiology, Vol 108, Iss 5, Pp 706-714 (2023)
Druh dokumentu: article
ISSN: 1469-445X
0958-0670
DOI: 10.1113/EP090729
Popis: Abstract We investigated the effect of a 31‐day ketogenic diet (KD) compared with a habitual, carbohydrate (CHO)‐based diet on total circulating natural killer (NK) CD3−CD56+, dim and bright subset count, and antigen‐stimulated CD3−CD56+ cell activation (CD69+) in response to exhaustive running. In a randomised, repeated‐measures, cross‐over study, eight trained, male endurance athletes ingested a 31‐day low‐CHO KD or their habitual diet (HD). On day 31, participants ran to exhaustion at 70% V̇O2max (∼3.5–4 h, ∼45–50 km). A low‐CHO ( 0.05). In conclusion, adaptation to a KD may alter the number of circulating NK cells but not their ability to activate to an antigenic challenge.
Databáze: Directory of Open Access Journals
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