Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats
| Autor: | Shadan Saberi, Aghdas Dehghani, Mehdi Nematbakhsh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Research in Pharmaceutical Sciences, Vol 11, Iss 1, Pp 65-72 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1735-5362 1735-9414 |
| Popis: | The angiotensin 1-7 (Ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin II through Mas receptor (MasR) or other unknown mechanisms. In the current study, the role of MasR and steroid hormone estrogen on renal blood flow response to Ang 1-7 administration was investigated in ovariectomized (OV) female rats. OV female Wistar-rats received estradiol (500 μg/kg/week) or vehicle for two weeks. In the day of the experiment, the animals were anesthetized, cannulated, and the responses including mean arterial pressure, renal blood flow (RBF), and renal vascular resistance at the constant level of renal perfusion pressure to graded infusion of Ang 1-7 at 0, 100 and 300 ng/kg/min were determined in OV and OV estradiol-treated (OVE) rats, treated with vehicle or MasR antagonist; A779. RBF response to Ang 1-7 infusion increased dose-dependently in vehicle (P dose |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|