The uniqueness of the plant mitochondrial potassium channel
| Autor: | Donato Pastore, Mario Soccio, Maura Nicoletta Laus, Daniela Trono |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | BMB Reports, Vol 46, Iss 8, Pp 391-397 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1976-6696 1976-670X |
| DOI: | 10.5483/BMBRep.2013.46.8.075 |
| Popis: | The ATP-inhibited Plant Mitochondrial K+ Channel (PmitoKATP)was discovered about fifteen years ago in Durum WheatMitochondria (DWM). PmitoKATP catalyses the electrophoreticK+ uniport through the inner mitochondrial membrane;moreover, the co-operation between PmitoKATP and K+/H+antiporter allows such a great operation of a K+ cycle tocollapse mitochondrial membrane potential (ΔΨ) and ΔpH, thusimpairing protonmotive force (Δp). A possible physiological roleof such ΔΨ control is the restriction of harmful reactive oxygenspecies (ROS) production under environmental/oxidative stressconditions. Interestingly, DWM lacking Δp were found to benevertheless fully coupled and able to regularly accomplish ATPsynthesis; this unexpected behaviour makes necessary to recastin some way the classical chemiosmotic model. In the whole,PmitoKATP may oppose to large scale ROS production bylowering ΔΨ under environmental/oxidative stress, but, whenstress is moderate, this occurs without impairing ATP synthesisin a crucial moment for cell and mitochondrial bioenergetics.[BMB Reports 2013; 46(8): 391-397] |
| Databáze: | Directory of Open Access Journals |
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