| Autor: |
Galashina Е.А., Bondarenko A.S., Ulyanov V.Yu., Klimov S.S. |
| Jazyk: |
ruština |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Саратовский научно-медицинский журнал, Vol 14, Iss 3, Pp 515-518 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2076-2518 |
| Popis: |
Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods. Main group consisted of 40 patients with implant-associated inflammation; first comparison group — of 20 patients with primary aseptic loosening of knee joint implant components; second comparison group — of 20 patients who underwent primary knee arthroplasty without complications in post-operative period; control group — of 20 conventionally healthy individuals. The levels of soluble receptor activator of nuclear factor kappa-B ligand and bone morphogenetic protein-2were defined in blood serum of all subjects by ELISA. Results. In patients of main group we observed more pronounced increase of soluble receptor activator of nuclear factor kappa-B ligand content and significant decrease of bone morphogenetic protein-2 content in blood serum; patients of first comparison group demonstrated activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased levels of bone morphogenetic protein-2 in blood serum; patients of second comparison group did not demonstrate any changes in the studied indexes. Conclusion. The activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased activity of bone morphogenetic protein-2 have leading role in the pathogenesis of implant-associated inflammation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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