Choroidal structure investigated by choroidal vascularity index in patients with inherited retinal diseases

Autor: Kia Bayat, Kiana Hassanpour, Hamideh Sabbaghi, Sahba Fekri, Narsis Daftarian, Tahmineh Motevasseli, Fatemeh Suri, Bahareh Kheiri, Mehdi Yaseri, Hamid Ahmadieh
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Retina and Vitreous, Vol 9, Iss 1, Pp 1-7 (2023)
Druh dokumentu: article
ISSN: 2056-9920
DOI: 10.1186/s40942-023-00457-w
Popis: Abstract Purpose To evaluate the choroidal structure in patients with inherited retinal diseases (IRDs) by investigating the choroidal vascularity index (CVI). Methods The present study was conducted on 113 IRD patients and 113 sex- and age-matched healthy individuals. Patients’ data was extracted from the Iranian National Registry for IRDs (IRDReg®). Total choroidal area (TCA) was determined between retinal pigment epithelium and choroid-scleral junction,1500 microns on either side of the fovea. Luminal area (LA) was considered as the black area corresponding to the choroidal vascular spaces, following Niblack binarization. CVI was calculated as the ratio of the LA to the TCA. CVI and other parameters were compared among different types of IRD and the control group. Results The IRD diagnosis included retinitis pigmentosa (n = 69), cone-rod dystrophy (n = 15), Usher syndrome (n = 15), Leber congenital amaurosis (n = 9), and Stargardt disease (n = 5). Sixty-one (54.0%) individuals of each of the study and control groups were male. The average CVI was 0.65 ± 0.06 in the IRD patients and 0.70 ± 0.06 in the control group (P
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