A Structured, Manual-Based Low-Level Intervention vs. Treatment as Usual Evaluated in a Randomized Controlled Trial for Adolescents with Extreme Obesity - the STEREO Trial

Autor: Yvonne Mühlig, André Scherag, Annika Bickenbach, Ulrike Giesen, Reinhard Holl, Rolf Holle, Wieland Kiess, Belinda Lennerz, Diana Lütke Brintrup, Anja Moss, Madlen Neef, Claudia Ose, Thomas Reinehr, Christina M. Teuner, Susanna Wiegand, Barbara Wolters, Martin Wabitsch, Johannes Hebebrand
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Obesity Facts, Vol 10, Iss 4, Pp 341-352 (2017)
Druh dokumentu: article
ISSN: 1662-4025
1662-4033
DOI: 10.1159/000475717
Popis: Background: To compare efficacy and safety of a manual-based low-level psychological intervention with treatment as usual (weight loss treatment). Methods: A two-armed randomized controlled trial without blinding and computer-based stratified block randomization included adolescents and young adults (14.0-24.9 years) with a BMI ≥ 30 kg/m2 at five German university hospitals. Primary outcomes were adherence (participation rate ≥ 5/6 sessions) and quality of life (DISABKIDS-37) 6 months after randomization. Secondary outcomes included depression, self-esteem, and perceived stress scores. Results: Of 397 screened adolescents, 119 (mean BMI 40.4 ± 7.0 kg/m2, 49.6% female) were randomized to the manual-based low-level intervention (n = 59) or treatment as usual (n = 60). We observed no group difference for adherence (absolute risk reduction 0.4%, 95% CI -14.7% to 15.5%; p = 1.0) or health-related quality of life (score difference 8.1, 95% CI -2.1 to 18.3; p = 0.11). Among all secondary outcomes, we detected explorative evidence for an effect on the DISABKIDS-37 ‘social exclusion' subscale (score difference 15.5; 95% CI 1.6-29.4; p = 0.03). 18/19 adverse events occurred in 26 participants, none were classified as serious. Conclusion: Adherence to a coping-oriented intervention was comparable to weight loss treatment, although it was weak in both interventions. Psychological interventions may help to overcome social isolation; further confirmation is required.
Databáze: Directory of Open Access Journals
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