| Autor: |
Yu-Ru Guo, Yi-Hao Hsu, An Liang, Wan-Jung Lu, Chi-Hao Wu, Hsiu-Chuan Lee, Shih-Yi Huang |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 19, Iss , Pp 522-536 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2015.09.050 |
| Popis: |
Epidemiological studies have reported that nutritional deficit of n-3 polyunsaturated fatty acids (PUFAs) is closely related to depression and cognitive impairment in middle and later life. This study investigated the preventive effects of n-3 PUFA-rich oils on the behavioural impairment of unchallenged aged prediabetic rats by using a Morris water maze (MWM) test and forced swimming test (FST). Twenty 102-wk-old male SD male rats received a 35% sucrose solution and were fed with fish oil or flaxseed oil diets for 8 wk. Both treatments reduced the production of IL-6 and non-esterified fatty acids significantly. Both treatments demonstrated significantly quicker MWM acquisition, shorter FST immobility time and higher levels of nerve growth factor than did the control group. Thus, n-3 PUFA-rich oil might produce protective effects by improving fasting blood sugar levels and reducing proinflammatory cytokine levels, thus preventing cognitive age-related impairments and depression-like behaviour in aged prediabetic rats. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect