POLYMORPHISM C(-344)T OF THE ALDOSTERONE SYNTHASE GENE AND ESSENTIAL ARTERIAL HYPERTENSION
| Autor: | O. S. Pavlova, S. E. Ogurtsova, M. M. Liventseva, E. V. Kovsh, Yu. V. Afonin, A. G. Mrochek |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Евразийский Кардиологический Журнал, Vol 0, Iss 4, Pp 42-47 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2225-1685 2305-0748 |
| DOI: | 10.38109/2225-1685-2016-4-42-47 |
| Popis: | ABSTRACT Objective. To study the association the aldosterone synthase gene (CYP11B2) C(-344)T polymorphism in ethnic Belarussians with essential hypertension (EH). Materials and methods. Genotyping of polymorphic marker C(-344)T of the CYP11B2 was performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in 585 people (391 patients with EH and 194 subjects with normal or optimal blood pressure (BP)). Results. The prevalence of C(-344)T polymorphism genotypes of the CYP11B2 gene did not differ between the groups of hypertensive patients - CC, CT, TT genotypes were detected in 105 (26.8%), 182 (46.6%), 104 (26.6%), and healthy people - in 48 (24.7%), 97 (50.0%), 49 (25.3%), respectively. There were not obtained differences in the level of BP, grade of EH depending on the mutant allele T polymorphism C(-344)T of the CYP11B2 gene among the group of 208 patients without the antihypertensive treatment. Conclusions. In patients with EH of Belarusian ethnicity it was observed equilibrium distribution of the C (50.1%) and T (49.9%) alleles polymorphism C(-344)T of the CYP11B2 gene. The genetic polymorphism C(-344)T of the gene CYP11B2 was not associated with the development of EH in the groups as well as under or after 45 years and taking into account gender differences. Key words: essential arterial hypertension, aldosterone synthase gene, genetic polymorphism. |
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